Card

Laboratory Maniac

Mana cost {2}{U}

If you would draw a card while your library has no cards in it, you win the game instead.

Part of 52 known combos, 12 of them two-card. 2 official rulings.

Bracket

B1 Exhibition — Not in the same deck as its two-card combo partners: Demonic Consultation, Tainted Pact, Leveler, Hermit Druid, Thought Lash, Paradigm Shift, Divining Witch, Dance with Calamity, Phyrexian Devourer, Oath of Druids, Sacred Guide, Griselbrand
B2 Core — Not in the same deck as its two-card combo partners: Demonic Consultation, Tainted Pact, Leveler, Hermit Druid, Thought Lash, Paradigm Shift, Divining Witch, Dance with Calamity, Phyrexian Devourer, Oath of Druids, Sacred Guide, Griselbrand
B3 Upgraded — Not in the same deck as its early two-card combo partners: Demonic Consultation, Tainted Pact, Leveler, Hermit Druid, Thought Lash, Paradigm Shift, Divining Witch, Phyrexian Devourer, Oath of Druids, Sacred Guide
B4 Optimized — allowed: No restriction beyond the banned list
B5 cEDH — allowed: No restriction beyond the banned list

Two-card combo with Demonic Consultation, Tainted Pact, Leveler, Hermit Druid, Thought Lash, Paradigm Shift, Divining Witch, Dance with Calamity, Phyrexian Devourer, Oath of Druids, Sacred Guide, Griselbrand (early with Demonic Consultation, Tainted Pact, Leveler, Hermit Druid, Thought Lash, Paradigm Shift, Divining Witch, Phyrexian Devourer, Oath of Druids, Sacred Guide)

Bracket: Lotus Vault analysis, with Commander Spellbook flags

52 known combos, 12 of them two-card.

2021-03-19 · Wizards of the Coast
If for some reason you can't win the game (because your opponent has cast Angel's Grace this turn, for example), you won't lose for having tried to draw a card from a library with no cards in it. The draw was still replaced.
2021-03-19 · Wizards of the Coast
If two or more players each control a Laboratory Maniac and each player is instructed to draw a number of cards, first the player whose turn it is draws that many cards. If this causes that player to win the game instead, the game is immediately over. If the game isn't over yet, repeat this process for each other player in turn order.

Rulings: Scryfall · Wizards of the Coast