Card

Mindcrank

Mana cost {2}

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Part of 5 known combos, 2 of them two-card. 1 official ruling.

Bracket

B1 Exhibition — Not in the same deck as its two-card combo partners: Bloodchief Ascension, Duskmantle Guildmage
B2 Core — Not in the same deck as its two-card combo partners: Bloodchief Ascension, Duskmantle Guildmage
B3 Upgraded — Not in the same deck as its early two-card combo partners: Bloodchief Ascension, Duskmantle Guildmage
B4 Optimized — allowed: No restriction beyond the banned list
B5 cEDH — allowed: No restriction beyond the banned list

Two-card combo with Bloodchief Ascension, Duskmantle Guildmage (early with Bloodchief Ascension, Duskmantle Guildmage)

Bracket: Lotus Vault analysis, with Commander Spellbook flags

5 known combos, 2 of them two-card.

Bloodchief Ascension + Mindcrank
Produces: Infinite mill, Near-infinite lifegain, Near-infinite lifegain triggers
View on Commander Spellbook
Duskmantle Guildmage + Mindcrank
Produces: Each opponent loses the game, Infinite mill, Near-infinite lifeloss
View on Commander Spellbook
Compost + Painter's Servant + Niv-Mizzet, the Firemind + Mindcrank
Produces: Infinite draw triggers, Near-infinite mill, Infinite card draw
View on Commander Spellbook

2017-11-17 · Wizards of the Coast
Damage dealt to an opponent usually causes that opponent to lose life. An opponent paying life also causes loss of life.

Rulings: Scryfall · Wizards of the Coast